Endocrine Abstracts

Thyroid hormones (THs) are known to regulate both lipid, glucose, and cholesterol metabolism. These effects have led to biochemical and molecular studies on the roles that they and their metabolites have on these processes. Additionally, TH analogs have been developed to improve metabolic conditions such as hypertriglyceridemia hypercholesterolemia, and obesity while minimizing side effects such as tachycardia and osteoporosis that occur in hyperthyroidism. Typically, these an...

While axiomatic, it is worth reflecting carefully when planning research. The first step requires careful review of the sequence of processes linking the current state of the art of the evidence, to the hypothesis, then to the question/s testing the hypothesis and on to the nature of evidence required to answer those questions., This is of course required well before any consideration of the “how” those questions can be answered. One of the confounders in this carefu...

While axiomatic, it is worth reflecting carefully when planning research. The first step requires careful review of the sequence of processes linking the current state of the art of the evidence, to the hypothesis, then to the question/s testing the hypothesis and on to the nature of evidence required to answer those questions., This is of course required well before any consideration of the “how” those questions can be answered. One of the confounders in this carefu...

Aims: We sought to audit our practice with the primary aim of improving diabetes service provision to our outpatients. Secondary Aims included developing a teaching document for junior doctors in OPD.Methodology: A retrospective audit of patient charts from monthly diabetes clinics from August to November inclusive examining our adherence to ISPAD Clinical Practice Consensus Guidelines 2014 as endorsed by BSPED.Findings: We audited...

Case history: 58 year old man presented with collapse secondary to profuse water diarrhoea. He had severe AKI, hypokalaemia, metabolic acidosis, hyponatraemia and hypercalcaemia. He had fluid and electrolyte replacement he in ICU, but profuse diarrhoea persisted and with it, was in hypotension and delerium. He had been having progressive diarrhoea and weight loss for 2 years while he was in South Africa.Investigations: Upper and lower GI endoscopies had ...

A 24-year-old male was referred to endocrinology with multiple severe atraumatic vertebral fractures. In the preceding 10 years the patient had experienced a bimalleolar ankle fracture and numerous metacarpal and metatarsal breakages unrelated to trauma. There was no family history of osteoporosis and examination did not reveal any abnormalities in scleral colour, stature, dentition or facial/thoracic morphology. Dual-energy x-ray absorptiometry demonstrated severe densitometr...

There are currently no robust methods for screening patients at risk of developing osteoporosis. Women tend to be more susceptible to low bone mineral density (BMD), whether its genetic, disease related, or menopausal and osteoporosis can also affect men. Access to dual energy x-ray absorption units (DEXA), is scarce and waiting lists are long. This has been exacerbated by the pandemic and the growing referral lists for radiology services. The burden of the disease processes i...

1% of western populations take chronic oral corticosteroids and this rises to 3% in subjects aged over 70 years old. When inhaled, topical and parenteral steroids are added to this burden, iatrogenic Cushing’s becomes a major health issue. High doses of medroxyprogesterone acetate can cause glucocorticoid effects and drug interactions may impair the metabolism of some glucocorticoids (eg fluticasone), thereby increasing their potency. Patients may develop the classical fe...

A 25-year lady was referred to GSTT for further management of thyrotoxicosis as she had relocated to London. The patient developed thyrotoxicosis during her pregnancy at the age of 23. During her pregnancy, she had significant weight loss. Her thyroid function test in September 2020 showed TSH 0.04 mU/lwith FT4 of 24.1 pmo/land TSH receptor antibody of 1.35 U/l. Hence she was started on propylthiouracil (PTU) during pregnancy. PTU was titrated down based on biochemical respons...

Case history: A fifteen year old female was seen in general paediatric clinic after multiple GP attendances based upon persistent maternal concerns for short stature (height below 0.4th centile). She was otherwise healthy, had achieved menarche at age 14, and had no dysmorphic features. She had been reviewed by endocrinology age ten and discharged with a diagnosis of familial short stature. Her mother’s height was on the 0.4th centile and her father’s on the 75th, re...